自从Nowell和Hungerfora~1在慢性粒细胞白血病患者中看到ph~1染色体以后,陆续为其他研究者所证实。我国,王志澄等也曾报导。近来逐渐注意对慢粒早期、缓解和急性变期的染色体变化进行研究。一些研究者认为,慢粒急性变患者中,除ph~1染色体外,还出现超二倍体和两个Ph~1染色体;另一些研究者认为,两个Ph~1染色体的出现为慢粒 Since Nowell and Hungerfora ~ 1 have seen ph ~ 1 chromosomes in patients with chronic myeloid leukemia, one after another has been confirmed by other researchers. China, Wang Zhicheng and others have also reported. Recently, attention has been gradually paid to the study of chromosome changes in early, mitigated and acute phase of slow granules. Some researchers believe that, in addition to the ph ~ 1 chromosome, hypercholesteromers and two Ph ~ 1 chromosomes also appear in patients with acute chronic ghrelin, and some other researchers believe that the appearance of two Ph ~ 1 chromosomes is CML