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目的观察单纯光疗或光疗联合白蛋白治疗足月新生儿重度黄疸的疗效。方法 112例新生儿重度黄疸患儿,随机分为对照组(54例)和观察组(58例),前者给予单纯光疗,观察组给予单纯光疗联合白蛋白注射,观察比较两组患儿血清总胆红素(TBIL)水平变化及不良反应发生情况。结果观察组TBIL(118.65±57.38)μmol/L、直接胆红素(DBIL)(3.67±0.95)μmol/L、间接胆红素(IBIL)(128.25±55.24)μmol/L;对照组TBIL(164.36±72.68)μmol/L、IDIL(7.62±2.45)μmol/L、IBIL(163.87±64.39)μmol/L;观察组胆红素降低水平显著优于对照组(P<0.05)。观察组不良反应发生率3.70%明显优于对照组的8.62%,但差异无统计学意义(P>0.05)。结论采用单纯光疗联合白蛋白治疗足月新生儿重度黄疸的临床疗效显著,能快速改善患儿黄疸情况,值得应用于临床医疗。
Objective To observe the curative effect of simple phototherapy or phototherapy combined with albumin on severe neonatal full-term jaundice. Methods One hundred and twelve neonates with severe jaundice were randomly divided into control group (n = 54) and observation group (n = 58). The former received simple phototherapy and the observation group received simple phototherapy combined with albumin injection. The levels of total serum Bilirubin (TBIL) levels and adverse reactions occurred. Results TBIL (118.65 ± 57.38) μmol / L, DBIL (3.67 ± 0.95) μmol / L, IBIL (128.25 ± 55.24) μmol / L and TBIL (164.36 ± 72.68μmol / L, IDIL (7.62 ± 2.45) μmol / L and IBIL (163.87 ± 64.39) μmol / L, respectively. The level of bilirubin in the observation group was significantly better than that in the control group (P <0.05). The incidence of adverse reactions in the observation group was 3.70% which was significantly better than that of the control group (8.62%), but the difference was not statistically significant (P> 0.05). Conclusions Pure phototherapy combined with albumin in the treatment of neonatal severe jaundice has a significant clinical effect, which can rapidly improve jaundice in children and is worthy of application in clinical practice.