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睾丸间质细胞是男性体内产生雄激素的主要细胞。干细胞可被诱导分化为具有雄激素分泌功能的睾丸间质样细胞,从而使其功能受到下丘脑与垂体调控,精确分泌维持生理功能需要的激素。故建立一套可靠高效的将干细胞诱导为雄激素分泌细胞的方法,对于治疗由于睾丸间质细胞异常引起的性腺功能低下意义重大。本文对近年来关于干细胞诱导分化为雄激素分泌细胞的研究进展予以综述。
Leydig cells are the main male androgen-producing cells in the body of men. Stem cells can be induced to differentiate into testicular interstitial cells with androgen secretion so that their function is regulated by the hypothalamus and pituitary gland and precisely secreting the hormones needed for physiological functions. Therefore, to establish a reliable and efficient method of inducing stem cells into androgen-secreting cells is of great significance for the treatment of hypogonadism caused by the abnormality of testicular stromal cells. This review summarizes recent advances in stem cell-induced differentiation into androgen-secreting cells.