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目的探讨弓形虫感染与异常妊娠结局的关系。方法选择2013年3-12月廊坊市第四人民医院妇产科就诊的126例异常妊娠结局妇女为实验组,本地区263例正常妊娠育龄妇女为对照组,采用酶联免疫吸附试验进行弓形虫IgM、IgG抗体检测,对两组数据进行处理和分析。结果异常妊娠结局妇女弓形虫IgM、IgG阳性率分别为7.94%和19.84%,对照组阳性率分别为1.90%和8.75%,两组差异均有统计学意义(χ2IgM=6.82、χ2IgG=9.70,P均<0.01);对照组弓形虫IgM、IgG阳性率明显低于各异常妊娠结局组,差异均有统计学意义(χ2自然流产=10.40、χ2早产=9.03、χ2胎停=4.32、χ2出生缺陷=4.04,P均<0.05)。4种异常妊娠结局妇女弓形虫IgM、IgG阳性率差异均无统计学意义(P均>0.05)。结论弓形虫感染可致严重异常妊娠结局,应采取综合措施预防孕妇弓形虫感染。
Objective To investigate the relationship between Toxoplasma gondii infection and abnormal pregnancy outcome. Methods 126 cases of abnormal pregnancy outcomes in the obstetrics and gynecology department of the Fourth People’s Hospital of Langfang City from March to December in 2013 were selected as the experimental group and 263 pregnant women of childbearing age in the region as control group. Toxoplasma gondii IgM, IgG antibody test, the two groups of data processing and analysis. Results The positive rates of IgM and IgG in Toxoplasma gondii were 7.94% and 19.84% respectively in pregnant women with abnormal pregnancy outcome. The positive rates in control group were 1.90% and 8.75%, respectively (χ2IgM = 6.82, χ2IgG = 9.70, P (P <0.01). The positive rates of IgM and IgG in Toxoplasma gondii in control group were significantly lower than those in abnormal pregnancy group (χ2 = 10.40, χ2 = 9.03, χ2 = 4.32, = 4.04, P <0.05). The positive rates of IgM and IgG in Toxoplasma gondii in 4 abnormal pregnancy outcomes were not significantly different (all P> 0.05). Conclusion Toxoplasma gondii infection can lead to serious abnormal pregnancy outcomes, and comprehensive measures should be taken to prevent Toxoplasma infection in pregnant women.