脓毒症的发病呈逐年上升趋势。对容量复苏和血管活性药物反应差的成年脓毒性休克患者,以及怀疑伴有肾上腺皮质功能低下、急性呼吸窘迫综合征、长期使用激素或出现儿茶酚胺抵抗性休克儿童可首选氢化可的松静脉使用。治疗应以既能够早期逆转休克获得较大疗效,而又减少或避免后期相关并发症为宜。 The incidence of sepsis is increasing year by year. Children with adult septic shock who have poor response to volume recovery and vasoactive drugs, and those who are suspected of having adrenal insufficiency, acute respiratory distress syndrome, long-term use of corticosteroids, or catecholaminergic shock may be the first choice for hydrocortisoneis. Treatment should be able to both early reversal of shock to obtain greater efficacy, but reduce or avoid late-related complications is appropriate.