We presented a case of giant neurofibromas arising from the jejunal mesentery of a 52-year-old man. The patient presented with epigastric fullness, and decrease of food intake, but without stigmata of neurofibromatosis-1. Ultrasonography,computed tomography (CT) and MR imaging revealed two large masses in the abdomen extending to the pelvis. Total resec-tion of the tumors together with corresponding segments of intestines was performed, Histological examination and immuno-cytochemistry for S-100 protein confirmed the masses to be multiple neurofibromas of the mesentery. We also discussed the clinical features, and treatment approaches of similar cases in literatures.