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目的 探讨凋亡调控基因p53、bcl-2和bax的蛋白表达及其与非何杰金氏恶性淋巴瘤（NHL）恶性程度之间的关系。方法 运用免疫组化方法检测了62例NHL的凋亡调控基因p53、bcl-2和bax的蛋白表达状态。结果 p53及Bcl-2蛋白的表达率、表达强度及阳性细胞密度均随NHL恶性程度的发展而逐渐增高，低度恶性组明显低于中度及高度恶性组（P<0.01），而中度及高度恶性组之间则无显著差异（P>0.05）；与此相反，Bax蛋白在低度恶性组的表达水平明显高于中度及高度恶性组（P<0.01）。结论 细胞凋亡调控异常在NHL的发生与发展中可能起重要作用，它们的表达状态和NHL的恶性程度密切相关。
Objective To investigate the expression of p53, bcl-2 and bax proteins and their relationship with the malignancy of non-Hodgkin’s lymphoma (NHL). Methods The protein expression of p53, bcl-2 and bax in 62 NHLs was detected by immunohistochemistry. Results The expression rates of p53 and Bcl-2 protein, the intensity of expression and the density of positive cells increased with the malignant degree of NHL. The expression of p53 and Bcl-2 protein in patients with low grade malignant tumors was significantly lower than that in moderate and high grade malignant tumors (P <0.01) (P> 0.05). In contrast, the expression of Bax protein in the low-grade group was significantly higher than that in the moderate-grade group and the high-grade group (P <0.01). Conclusion The abnormal regulation of apoptosis may play an important role in the occurrence and development of NHL. The expression of NHL is closely related to the malignant degree of NHL.