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目的探讨丙泊酚联合米非司酮用于无痛人工流产的临床效果。方法将孕8~10周需终止妊娠并要求无痛人工流产的200例孕妇随机分为观察组(100例)和对照组(100例)。前者在用丙泊酚行无痛人工流产前2 d米非司酮50 mg口服1次;后者不用米非司酮。观察2组镇痛效果及术中宫颈松弛扩张情况、宫缩幅度、术中出血量及人工流产综合征的发生率。结果丙泊酚联合米非司酮应用于无痛人工流产,镇痛率100%,手术时间缩短,宫颈充分软化率高,术中用药少,人工流产综合征发生率低,术中出血量无明显增加。结论丙泊酚联合米非司酮应用于无痛人工流产,具有效果好、不良反应小等优点。
Objective To investigate the clinical effect of propofol combined with mifepristone on painless induced abortion. Methods 200 pregnant women who needed to terminate pregnancy and required painless abortion during pregnancy were randomly divided into observation group (100 cases) and control group (100 cases). The former was given oral mifepristone 50 mg twice a day before painless artificial abortion with propofol; the latter without mifepristone. The analgesic effect and intraoperative cervical relaxation and expansion, contractions amplitude, intraoperative blood loss and the incidence of induced abortion syndrome were observed. Results Propofol combined with mifepristone used in painless abortion, analgesic rate was 100%, operation time was shortened, cervical full softening rate, less intraoperative medication, low incidence of induced abortion syndrome, intraoperative blood loss obviously increase. Conclusion Propofol combined with mifepristone used in painless abortion, with good results, adverse reactions and other advantages.