Dimerization of diferent nanocomponents in single nanoparticles becomes interesting due to not only inheritance of properties of both components but also generation of new properties associated with strong coupling of the two components. As a class of emerging nanomaterials, interfaced heterogeneous nanodimers(IHNDs) are atracting more atentions in the ield of materials research, in particular,nanoscience and nanotechnology. his review provides a timely and comprehensive overview on the general principles for the synthesis of IHNDs and typical examples of IHNDs made of various compositional combinations. he current challenges related to the synthesis and characterization of IHNDs are summarized at the end of the review and future research directions are also discussed. Dimerization of diferent nanocomponents in single nanoparticles becomes interesting due to not only only inheritance of properties of both components but also generation of new properties associated with strong coupling of the two components. As a class of emerging nanomaterials, interfaced heterogeneous nanodimers (IHNDs) are atracting more atentions in the ield of materials research, in particular, nanoscience and nanotechnology. his review provides a timely and comprehensive overview on the general principles for the synthesis of IHNDs and typical examples of IHNDs made of various compositional combinations. he current challenges related to the synthesis. and characterization of IHNDs are summarized at the end of the review and future research directions are also discussed.