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目的:探讨中西医联合治疗对神经性耳鸣患者症状体征评分及血液5-羟色胺(5-HT)水平的影响。方法:选取2015年6月至2016年12月进行治疗的160例神经性耳鸣患者,将患者按照随机数字表法分为对照组和观察组,各80例。对照组使用右旋糖酐进行注射治疗,观察组在对照组的治疗基础上使用中医捻转针刺法治疗。分别对两组患者治疗前后的临床症状评分以及5-HT水平进行比较,同时比较两组患者的治疗有效率和不良反应发生率。结果:治疗前两组患者临床症状评分差异无统计学意义(P>0.05);治疗后观察组6项评分均显著低于对照组(P<0.05),观察组的治疗有效率显著高于对照组(P<0.05)。两组治疗前5-HT水平比较差异无统计学意义(P>0.05);治疗后两组血清5-HT水平显著下降(P<0.05),且观察组显著低于对照组(P<0.05)。两组不良反应发生率差异无统计学意义(P>0.05)。结论:中西医联合治疗神经性耳鸣具有更好的临床疗效,可能与其调节5-HT水平有关,并且此种方法具有一定安全性。
Objective: To investigate the effect of traditional Chinese and western medicine on symptoms and signs score and 5-hydroxytryptamine (5-HT) level in neurotic tinnitus patients. Methods: A total of 160 patients with neurogenic tinnitus were selected from June 2015 to December 2016. The patients were divided into control group and observation group according to the random number table. Each group included 80 cases. The control group was treated with dextran injection. The observation group was treated with Chinese traditional twist acupuncture on the basis of the control group. The clinical symptom scores and the levels of 5-HT before and after treatment were compared between the two groups. At the same time, the treatment efficiency and the incidence of adverse reactions in both groups were compared. Results: There was no significant difference in the scores of clinical symptoms between the two groups before treatment (P> 0.05). After treatment, the scores of the 6 groups were significantly lower than those of the control group (P <0.05), and the treatment efficiency of the observation group was significantly higher than that of the control group Group (P <0.05). The levels of 5-HT before and after treatment in the two groups were not significantly different (P> 0.05). The levels of 5-HT in the two groups were significantly decreased (P <0.05), and the levels in the observation group were significantly lower than those in the control group (P <0.05) . There was no significant difference in the incidence of adverse reactions between the two groups (P> 0.05). Conclusion: TCM and WM combined treatment of neurological tinnitus has better clinical efficacy, may be related to its regulation of 5-HT level, and this method has some safety.