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目的研究TBX21基因的rs16947078位点的多态性与哮喘易感性的关系。方法应用基质辅助激光解吸附电离飞行时间质谱(MALDI-TOF-MS)平台及MassARRAY-IPLEX技术,分别对重庆地区汉族人群中199名正常对照组和223名哮喘患者组的TBX21基因rs16947078位点进行检测并分析其基因型及等位基因分布情况,研究TBX21基因rs16947078位点的多态性与哮喘易感性间的关系。结果 TBX21基因rs16947078位点基因型和等位基因在病例组与对照组间均存在显著差异,P值分别为0.010和0.011;对年龄和性别进行校正后,相对于AA基因型,AG基因型的人群患哮喘的风险增加(OR=9.433,95%CI:1.170~76.022);等位基因G的携带者患哮喘的风险也有所增加(OR=9.232,95%CI:1.152~74.006)。结论研究结果提示TBX21基因中rs16947078位点与哮喘的易感性相关。
Objective To study the relationship between rs16947078 polymorphism of TBX21 gene and asthma susceptibility. Methods The genotypes of rs16947078 of TBX21 gene in 199 healthy controls and 223 asthma patients in Han population of Chongqing were genotyped by using matrix-assisted laser desorption / ionization time of flight mass spectrometry (MALDI-TOF-MS) and MassARRAY-IPLEX The genotype and allele distribution of TBX21 gene were detected and analyzed. The relationship between rs16947078 polymorphism and susceptibility to asthma was studied. Results The genotype and allele of rs16947078 in TBX21 gene were significantly different between the case group and the control group (P = 0.010 and 0.011, respectively). After adjusting for age and gender, the genotypes of AG genotype There was an increased risk of asthma in the population (OR = 9.433, 95% CI: 1.170 to 76.022); carriers of allele G also had an increased risk of asthma (OR = 9.232, 95% CI: 1.152 to 74.006). Conclusion The results suggest that rs16947078 in TBX21 gene is associated with asthma susceptibility.