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目的探讨心肌肌钙蛋白l对呼吸机相关性肺炎(ventilator-associated pneumonia,VAP)患者的临床意义。方法对36例VAP患者和28例非VAP患者测定心肌肌钙蛋白I(cTn I),对两组患者的cTn I和病死率进行比较分析。结果VAP组与非VAP组两组患者的cTn I有非常明显差异(P<0.01).VAP组患者病死率为61%,较非VAP组患者病死率有明显差异(P<0.05)。结论VAP患者cTnI升高,与患者肺部感染及预后相关。cTnI升高患者预后差。cTnI测定可作为VAP患者预后监测的一项可靠指标。
Objective To investigate the clinical significance of cardiac troponin 1 in patients with ventilator-associated pneumonia (VAP). Methods Cardiac troponin I (cTn I) was measured in 36 VAP patients and 28 non-VAP patients. The cTn I and case fatality rates were compared between the two groups. Results There was a significant difference in cTn I between VAP group and non-VAP group (P <0.01). The mortality rate in VAP group was 61%, which was significantly different from that in non-VAP group (P <0.05). Conclusions Patients with VAP have elevated cTnI and are associated with lung infection and prognosis. Patients with elevated cTnI have poor prognosis. The cTnI assay can be used as a reliable indicator of prognosis in patients with VAP.