为找到一种简便易行的方法对α-硝基酮类化合物进行合成。采用取代的苯甲酰氯和硝基甲烷为原料,经过两步反应来获得有机反应中重要的中间体α-硝基酮。结果显示,通过该方法合成了12种取代的硝基苯乙酮,其产率在68%-95%之间,结构通过1H NMR验证正确。由此可知,使用取代的苯甲酰氯和硝基甲烷为原料,可以获得相应的硝基酮,并有较为满意的产率。 In order to find an easy way to synthesize α-nitro ketones. Substituted benzoyl chloride and nitromethane as raw materials, through two-step reaction to obtain an important organic intermediate α-nitro ketone. The results showed that 12 substituted nitroacetophenones were synthesized by this method. The yield was between 68% -95%. The structures were confirmed by 1H NMR. It can be seen that the use of substituted benzoyl chloride and nitromethane as raw materials, you can get the corresponding nitro ketone, and a more satisfactory yield.