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目的比较不同剂量吡喹酮治疗慢性血吸虫病的临床疗效。方法选取黄石市阳新县陶港镇中心血防站2014年6月—2016年6月收治的慢性血吸虫病患者174例,随机分为低剂量组和常规剂量组,各87例。低剂量组患者给予吡喹酮30 mg/kg,常规剂量组患者给予吡喹酮40 mg/kg。比较两组患者的临床疗效、粪便虫卵转阴率,观察患者不良反应发生情况。结果两组患者治疗总有效率、粪便虫卵转阴率、不良反应发生率比较,差异无统计学意义(P>0.05)。结论采用低剂量吡喹酮与常规剂量吡喹酮治疗慢性血吸虫病的疗效相当,均可有效改善患者的临床症状及体征,促进粪便虫卵转阴,且安全性好,因此在保证临床疗效的前提下应选择小剂量吡喹酮治疗。
Objective To compare the clinical efficacy of different doses of praziquantel in the treatment of chronic schistosomiasis. Methods A total of 174 patients with chronic schistosomiasis were enrolled from June 2014 to June 2016 in Taogang Town Center Blood-Stabilization Station of Yangxin County, Huangshi City, and randomly divided into low dose group and conventional dose group, with 87 cases each. Patients in the low-dose group received praziquantel 30 mg / kg and patients in the conventional dose group received praziquantel 40 mg / kg. The clinical curative effect of the two groups of patients was compared, the negative rate of fecal egg was observed and the incidence of adverse reactions was observed. Results The total effective rate of treatment, fecal egg negative rate, the incidence of adverse reactions, the difference was not statistically significant (P> 0.05). Conclusions The efficacy of low-dose praziquantel and conventional praziquantel in the treatment of chronic schistosomiasis is comparable, which can effectively improve the clinical symptoms and signs of patients and promote the negative conversion of stool egg, and the safety is good. Therefore, in order to ensure clinical efficacy Under the premise should choose a small dose of praziquantel treatment.