安徽古代盛行炼丹,早在西汉时淮南王刘安就在寿春(今寿县)聚集数千名宾客研讨学问,写下了很多著作,刘安等人还从事炼丹。传世的《淮南子》和《淮南万毕术》中就提到了汞、铅、丹砂、曾青、雄黄等炼丹物质及其变化,其中关于“曾青得铁则化为铜”的记载,即天然硫酸铜溶液与铁接触,铁能取代硫酸铜里的铜,就是现代的金属置换反应,也是我国后来“胆水炼铜法”的理论基础,据《郡国志》、《广舆记》、《江南通志》、《嘉庆合肥县志》等书记载,汉末中国炼丹 Ancient Anhui was a popular alchemist. As early as in the Western Han Dynasty, Liu An, a Huainan king, gathered thousands of guests in Shouchun (now Shou County) to study and write a lot of works. Liu An and others also engaged in alchemy. The handed down “Huainanzi” and “Huainan Wan Bishu” mentioned mercury, lead, dansha, Zengqing, realgar, and other alchemy substances and their changes, including the record that “Zengqing’s iron was converted to copper”. Natural copper sulfate solution is in contact with iron. Iron can replace copper in copper sulfate. It is a modern metal replacement reaction. It is also the theoretical foundation for China’s later “brick water smelting copper method.” “Jiangnan Tongzhi” and “Jiaqing Hefei County Chronicle” and other books recorded that in the late Han Dynasty, China’s alchemy