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目的研究持续床旁血液滤过治疗产后合并急性肾衰竭(ARF)的疗效。方法 32例产后合并急性肾衰竭患者,均给予持续床旁血液滤过治疗,统计治疗效果,并比较治疗前后生化指标[血清尿素氮(BUN)、血清肌酐(SCr)、白细胞(WBC)、血pH值]及炎症因子[肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、C反应蛋白(CRP)]水平变化。结果 32例患者经过治疗,27例痊愈(尿量增多,肾功能好转),3例转为慢性肾衰竭,2例死亡。治疗后BUN、SCr、WBC水平明显低于治疗前,血pH值高于治疗前,差异均具有统计学意义(P<0.05)。治疗后IL-6、TNF-α、CRP水平明显低于治疗前,差异均具有统计学意义(P<0.05)。结论持续床旁血液滤过治疗产后合并急性肾衰竭,临床疗效显著,能明显改善机体内环境,并降低炎症因子水平,具有较高临床运用价值。
Objective To study the efficacy of continuous bedside hemofiltration in the treatment of postpartum acute renal failure (ARF). Methods 32 postpartum patients with acute renal failure were treated with continuous bedside hemofiltration, and the effect of treatment was compared. Before and after treatment, the serum levels of BUN, SCr, WBC, (pH value) and inflammatory cytokines (TNF-α, IL-6, C-reactive protein (CRP)] were measured. Results 32 patients were treated, 27 patients recovered (increased urine output, renal function improved), 3 patients converted to chronic renal failure, 2 patients died. After treatment BUN, SCr, WBC levels were significantly lower than before treatment, the blood pH value higher than before treatment, the difference was statistically significant (P <0.05). After treatment, the levels of IL-6, TNF-α and CRP were significantly lower than those before treatment (P <0.05). Conclusion Continuous bedside hemofiltration in the treatment of postpartum acute renal failure has significant clinical effect, which can significantly improve the internal environment and reduce the level of inflammatory cytokines, which has a high clinical value.