沙利度胺(thalidomide,反应停)具有免疫抑制特性,已用于治疗盘状红斑狼疮、白塞病等皮肤粘膜疾病。现用于治疗HIV感染者口疮性溃疡取得疗效。 14例已被确诊为HIV感染并患口疮性溃疡的男性患者,用沙利度胺(300mg/d)与安慰剂对照治疗7天,对安慰剂无效者再给予沙利度胺300mg/d,对300mg/d无效者增至600mg/d。结果:沙利度胺300mg/d组有效8/ Thalidomide (thalidomide, response stop) has immunosuppressive properties, has been used to treat discoid lupus erythematosus, Behcet’s disease and other skin and mucous membranes. Now used to treat aphthous ulcers in HIV-infected patients achieved curative effect. Fourteen men who had been diagnosed with HIV infection and had aphthous ulcers were treated with thalidomide (300 mg / d) for 7 days versus placebo, thalidomide 300 mg / d for those who did not respond to placebo, 300mg / d ineffective to 600mg / d. Results: thalidomide 300mg / d group effective 8 /