类脂A的基本结构为两个酰胺基葡糖通过β(1→6)甙键连接构成基本骨架,磷酸基连接在C_1,C_4′位。其他骨架碳上分别有脂肪酸以酯键相连。现已确立了类脂A 的化学结构。并证实类脂A 是内毒素的活性中心。磷酸酯基的存在及结合位置,以及与类脂A 中氨基葡糖主链相连的酰基的组成及结合位置,严重影响类脂A 生物活性的表达。过去 The basic structure of lipid A is that two amido glucosides are connected by β (1 → 6) glycosidic bonds to form a basic skeleton, and the phosphate groups are connected to C_1 and C_4 ’positions. The other skeletons have fatty acids attached to them by ester linkages, respectively. The chemical structure of lipid A has now been established. And confirmed that lipid A is the active center of endotoxin. The presence and binding sites of the phosphate groups, as well as the composition and the binding sites of the acyl groups attached to the glucosamine backbone in lipid A, seriously affect the expression of the lipid A biological activity. past