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本篇代表日本在中成药研究新动向的一个方面。从复方中找出抗糖尿病的活性成分,进而寻找含有相似成分的资源,以供药用。从该文中还启示我们:一、八味丸水提浸膏的药理功效不等于八味丸原粉的药理功效,从而说明剂型改革要慎重;二、由于STZ糖尿病模型的局限性,单味有效成分并不能代表整个方剂。因此多指标的药理试验及临床药理试验是不容忽视的。
This article represents one aspect of Japan’s new trends in Chinese medicine research. Find out the anti-diabetic active ingredients from the compound, and then look for resources containing similar ingredients for medicinal purposes. From the article, we also inspire us: First, the pharmacological efficacy of Bawei Pills water extract extract does not equal to the pharmacological efficacy of Bawei Pill original powder, thus indicating that dosage form reform must be prudent; Second, due to the limitations of STZ diabetes model, single effective The ingredients do not represent the entire formula. Therefore, multiple indicators of pharmacological tests and clinical pharmacological tests can not be ignored.