炎症性肠病的当代治疗山西医学院第一附属医院（０３０００１）耿引凤对ＩＢＤ的治疗需根据病情轻重、病程长短、病变范围及个体免疫状态等制定综合治疗措施。一、药物治疗１，水杨酸偶氮磺胺吡啶（ＳＡＳＰ）或５—氨基水杨酸（５—ＡＳＡ），为治疗ＩＢＤ的轻、中型首选药。ＳＡＳＰ经结肠细菌作用释出５—ＡＳＡ及磺胺吡啶，ＳＡＳＰ的治疗作用主要来自５—ＡＳＡ，可抑制前列腺素、血栓素和白三烯等炎性介质；阻滞某些细菌肽的趋化活性；清除氧自由基等，从而减轻肠道炎症。其治疗作用与用量有关，ＳＡＳＰ４～６克／天有效率分别为６７％和７７％。但副作用发生亦随用药量增加而增高。５—ＡＳＡ不含磺胺吡啶，但口服后迅速由小肠吸收，可出现急慢性肾毒性作用。近年来研究出许多可达到远端小肠和结肠的新型口服５—ＡＳＡ制剂，并有局部灌肠用的５─ＡＳＡ制剂，但来源较困难、价格昂贵，国内尚不能或尚未生产。鉴于国内ＩＢＤ多为轻、中型，我们应用自行研制的ＳＡＳＰ栓治疗ＩＢＤ５２例，总有效率达９５％。并与山医三院及省内６家综合医院观察溃疡结肠炎１００例，ＳＡＳＰ栓治疗总有效率９３．８％，口服对照组总有效率７３．８％。２．皮质固醇类药。为重型及活动型ＩＢＤ首选，可静脉滴注 Contemporary treatment of inflammatory bowel disease First Affiliated Hospital of Shanxi Medical University (030001) GENG Yin-feng Treatment of IBD need to develop comprehensive treatment based on severity, duration of the disease range and individual immune status and other comprehensive treatment. First, the drug treatment 1, salicylazosulfapyridine (SASP) or 5-aminosalicylic acid (5-ASA), for the treatment of IBD light and medium preferred drug. 5-ASA and sulfapyridine released by SASP via colonic bacteria. The therapeutic effect of SASP is mainly from 5-ASA, which inhibits the inflammatory mediators such as prostaglandin, thromboxane and leukotriene; blocks the chemotactic activity of certain bacterial peptides ; Remove oxygen free radicals, thereby reducing intestinal inflammation. Its therapeutic effect and dosage, SASP4 ~ 6g / day effective rate was 67% and 77%. However, the incidence of side effects also increased with the dose increased. 5-ASA does not contain sulfapyridine, but quickly absorbed by the small intestine after oral administration, there may be acute and chronic renal toxicity. In recent years, many new oral 5-ASA preparations that reach the distal small intestine and colon have been developed, and 5-ASA preparations for local enema have been developed. However, the sources are difficult and expensive, and they can not or have not yet been produced domestically. In view of the domestic IBD mostly light, medium, we use self-developed SASP bolt treatment of IBD52 cases, the total effective rate of 95%. 100 cases of ulcerative colitis were observed with the Third Affiliated Hospital of Shandong Medical University and six general hospitals in the province. The total effective rate of SASP suppositories was 93.8%, and the total effective rate of oral administration was 73.8%. 2. Corticosteroids. For heavy and mobile IBD preferred, intravenous infusion