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目的:探讨老年社区获得性肺炎患者TNF-α和sTREM-1表达水平及其临床意义。方法:从我院选择48例社区获得性肺炎患者为CAP组(重症组和普通组),另选取对照组48例。收集两组患者的血浆及BALF,分别收集重症组患者住院后1天、4天的血浆和BALF,对比各组sTREM-1和TNF-α的表达水平。结果:对照组TNF-α和sTREM-1的表达水平均低于CAP组(P<0.05);重症患者的TNF-α和sTREM-1表达水平高于普通组和健康对照组(P<0.05)。重症患者TNF-α表达水平与对照组无显著差异(P>0.05),而s TREM-1表达高于对照组,差异有统计学意义(P<0.05)。结论:TNF-α和sTREM-1表达水平与CAP的发病过程密切相关,其表达水平与CAP的严重程度呈正相关。
Objective: To investigate the expression of TNF-α and sTREM-1 in elderly patients with community-acquired pneumonia and its clinical significance. Methods: 48 cases of community-acquired pneumonia were selected as CAP group (severe group and normal group) from our hospital and 48 cases of control group. The plasma and BALF of two groups were collected and the plasma and BALF were collected at 1 and 4 days after hospitalization in critically ill patients. The expression levels of sTREM-1 and TNF-α in each group were compared. Results: The expression levels of TNF-α and sTREM-1 in the control group were lower than those in the CAP group (P <0.05). The levels of TNF-α and sTREM-1 in the severe patients were significantly higher than those in the normal group and the healthy control group . The expression of TNF-α in critically ill patients was not significantly different from that in the control group (P> 0.05), while the expression of s-TREM-1 in the critically ill patients was significantly higher than that in the control group (P <0.05). CONCLUSION: The expression of TNF-α and sTREM-1 is closely related to the pathogenesis of CAP. The expression level of TNF-α and sTREM-1 is positively correlated with the severity of CAP.