心力衰竭(心衰)是21世纪心血管医生面临的两大挑战之一。研究表明他汀类药物干预可给心衰治疗带来益处,但其作用机制不明[1]。研究显示心肌肌浆网钙调控蛋白的表达异常在慢性心衰的病程进展中起着重要作用[2]。本实验通过用超容量负荷联合压力负荷制备家兔心衰模型,观察辛伐他 Heart failure (heart failure) is one of the two major challenges that cardiologists face in the 21st century. Studies have shown that statin therapy can bring benefits to heart failure treatment, but its mechanism of action is unknown [1]. Studies have shown that abnormal expression of cardiac sarcoplasmic reticulum calcium regulatory protein plays an important role in the progression of chronic heart failure [2]. In this experiment, rabbits with heart failure model were prepared by super-capacity load and pressure load, and simvastatin