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目的:观察四逆汤加味联合化疗、放疗、内分泌治疗等综合措施治疗晚期乳腺癌术后的临床疗效。方法:将60例患者在术后进行化、放疗和内分泌治疗期间联合口服四逆汤加味治疗3月。观察治疗前后临床症状积分变化、临床症状缓解率和实体瘤近期疗效。结果:疲乏、纳差、怕冷、便秘症状积分变化情况治疗前后比较,差异均有非常显著性意义(P<0.01);胸胁胀痛、淋巴结肿大、月经不调症状积分变化情况治疗前后比较,差异均有显著性意义(P<0.05);失眠、多汗症状积分有所改善,但差异均无显著性意义(P>0.05)。临床症状缓解总有效率为73.33%。实体瘤近期总有效率为51.67%,疾病控制率为76.67%。结论:四逆汤加味治疗能提高晚期乳腺癌患者术后对放、化疗的耐受性及依从性,减少毒副作用,改善生活质量。
Objective: To observe the curative effect of Sini Decoction combined with chemotherapy, radiotherapy and endocrine therapy in the treatment of advanced breast cancer after operation. Methods: Sixty patients were treated with oral Sini Decoction during the course of radiotherapy and endocrine therapy for 3 months. Observed before and after treatment of clinical symptom score changes, clinical symptoms and solid tumor immediate response. Results: There were significant differences in fatigue, anorexia, cold and constipation symptom scores before and after treatment (P <0.01); chest X-ray pain, swollen lymph nodes and irregular menstruation symptom before and after treatment (P <0.05). The score of insomnia and hyperhidrosis symptom was improved, but the difference was not significant (P> 0.05). The total effective rate of clinical symptom relief was 73.33%. The recent total effective rate of solid tumors was 51.67%, disease control rate was 76.67%. Conclusion: Modified Sini Decoction can improve the tolerance and compliance of radiotherapy and chemotherapy in patients with advanced breast cancer, reduce the side effects and improve the quality of life.