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我院在1981年～1983年期间,采用强的松、环磷酰胺治疗肾病综合征,并对具有血液高凝状态的病人加用肝素治疗,取得了较好的临床效果。现将资料较完整的12例总结如下。一般资料全部病例均为住院病人。12例中男7例,女5例,年龄15～53岁。病程3～6个月4例,7个月～1年3例,1年以上～3年5例。12例入院时具有明显水肿,大量蛋白尿(>3.5g/24h),低白蛋白血症(<3.0g/dl)和高胆固醇血症(>250mg/dl)。1/4病例有高血压,1/3病例有氮质血症。尿镜检:7例少量红细胞,2例(+),3例((?))。治疗方法1.强的松+环磷酰胺治疗。强的松30mg/d,分3次服。环磷酰胺200mg+生理盐水20ml 缓慢静脉注射,每日1次,连续用药20～30天后,环磷酰胺改为口服。水肿消退,尿蛋白减至少量后逐渐减量,直至尿
Our hospital from 1981 to 1983, the use of prednisone, cyclophosphamide in the treatment of nephrotic syndrome, and blood hypercoagulability patients with heparin therapy, and achieved good clinical results. The information is more complete 12 cases are summarized below. General information All cases are inpatient. There were 7 males and 5 females in 12 cases, aged 15-53 years. Duration of 3 to 6 months in 4 cases, 7 months to 1 year in 3 cases, 1 year to 3 years in 5 cases. Twelve had significant edema, massive proteinuria (> 3.5g / 24h), hypoalbuminemia (<3.0g / dl) and hypercholesterolemia (> 250mg / dl) on admission. One in four cases had hypertension and one third had azotemia. Urinary microscopy: a small amount of red blood cells in 7 cases, 2 cases (+), 3 cases ((?)). Treatment 1. Prednisone + cyclophosphamide treatment. Prednisone 30mg / d, 3 times service. Cyclophosphamide 200mg + saline 20ml intravenous injection, once daily, 20-30 consecutive days after treatment, cyclophosphamide to oral. Edema subsided, reduced to a small amount of urine protein and then gradually reduced until the urine