蓖麻毒素(RT)是存在于蓖麻籽中的一种糖蛋白,它能使真核生物细胞内的核糖体60S亚基灭活,从而使蛋白质合成抑制而导致细胞死亡。鉴于蓖麻毒素强烈毒性,国外许多学者对它进行了深入研究。在应用方面,第一、二次世界大战期间曾考虑作为候选化学战剂,近期在抗癌方面做了大量研究。70年代,Lin等观察到RT对小鼠的艾氏腹水瘤有治疗作用,在许多实验过的人癌移植物中,RT效果与目前临床上使 Ricin (RT) is a glycoprotein present in castor seeds that inactivates the 60S subunit of ribosomal proteins in eukaryotic cells, thereby inhibiting protein synthesis and resulting in cell death. In view of the strong toxicity of ricin, many foreign scholars have conducted in-depth study. In terms of applications, it was considered as a candidate chemical warfare agent during the First World War and World War II, and a great deal of recent research on anti-cancer has been done. In the 1970s, Lin et al. Observed that RT has a therapeutic effect on Ehrlich ascites tumor in mice. In many experimental human carcinoma transplants, the effect of RT on the clinical efficacy