消化性溃疡包括胃和十二指肠溃疡,为临床常见病,一般认为其发生是由攻击因素和防御因素失衡引起的,胃酸被认为是最主要的攻击因素,而防御因素包括粘液层、粘膜屏障、细胞再生、粘膜血流及前列腺素等。本文将从减少攻击因素及增强防御因素两方面对治疗消化性溃疡的药物进行讨论。1 减少攻击因素的抗溃疡药物 减少攻击性因素的抗溃疡药物主要有抗酸药和抑酸药两大类。其中抑酸药又分为H_2受体拮抗剂、质子泵抑制剂 Peptic ulcer, including gastric and duodenal ulcer, is a common clinical disease, it is generally believed that the occurrence of peptic ulcer caused by the imbalance between attack and defense factors, stomach acid is considered to be the most important attack factors, and defensive factors, including mucus layer, mucosa Barrier, cell regeneration, mucosal blood flow and prostaglandin. This article will discuss the treatment of peptic ulcer drugs from both the reduction of attack factors and the enhancement of defensive factors. 1 to reduce the attack of anti-ulcer drugs to reduce the aggressive anti-ulcer drugs mainly antacid and antacids two categories. Which acid-suppressing drugs are divided into H 2 receptor antagonists, proton pump inhibitors