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目的:探讨99Tcm-2β-[N,N′-双(2-巯乙基)乙撑二胺基]甲基-3β-(4-氯苯基)托烷(TRODAT-1)多巴胺转运蛋白(transporter,DAT)显像在帕金森病(PD)早期诊断中的应用价值。方法:对50例早期PD患者和12例健康对照者行脑DAT99Tcm-TRODAT-1SPECT断层显像。利用感兴趣区技术测定纹状体与小脑部位DAT比值。结果:健康对照组双侧纹状体摄取差异无显著性。早期PD患者双侧纹状体与小脑部位比值分别较健康对照组明显降低(P均<0·001)。起病肢体对侧纹状体与小脑部位比值比起病肢体同侧纹状体与小脑部位比值明显降低(P均<0·001)。结论:脑99Tcm-TRODAT-1SPECT显像有助于PD的早期诊断。
Objective: To investigate the effects of 99Tcm-2β- [N, N’-bis (2-mercaptoethyl) ethylenediamino] methyl-3β- (4- chlorophenyl) tropane (TRODAT- transporter, DAT imaging in the early diagnosis of Parkinson’s disease (PD). Methods: Fifty patients with early PD and 12 healthy controls underwent brain DAT99Tcm-TRODAT-1 SPECT imaging. The region of interest (DZ) was used to determine the ratio of DAT in striatum to cerebellum. Results: There was no significant difference in the uptake of bilateral striatum between healthy controls. The ratio of bilateral striatum and cerebellum in patients with early PD were significantly lower than those in healthy controls (all P <0.001). The ratio of striatum to cerebellum in the contralateral limbs was significantly lower than that in the ipsilateral striatum and cerebellum (P <0.001). Conclusion: Brain 99Tcm-TRODAT-1 SPECT imaging is helpful for the early diagnosis of PD.