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目的探讨兴奋性氨基酸在脑梗塞发病机制中的作用。方法采用高效液相层析法测定４１例急性脑梗塞患者和２８例对照者的脑脊液谷氨酸和天门冬氨酸含量。结果脑梗塞患者脑脊液谷氨酸和天门冬氨酸含量显著高于对照组（Ｐ均＜０．００１），谷氨酸、天门冬氨酸含量与梗塞体积、神经功能缺损程度之间均呈显著正相关（Ｐ均＜０．００１）。结论兴奋性氨基酸参与了脑梗塞的病理生理过程
Objective To investigate the role of excitatory amino acids in the pathogenesis of cerebral infarction. Methods The contents of glutamic acid and aspartic acid in cerebrospinal fluid of 41 patients with acute cerebral infarction and 28 controls were measured by HPLC. Results The contents of glutamic acid and aspartic acid in cerebrospinal fluid in patients with cerebral infarction were significantly higher than those in control group (all P <0.001). There was significant difference between glutamic acid, aspartic acid content and infarct volume and neurological deficit Positive correlation (P <0.001). Conclusion Excitatory amino acids are involved in the pathophysiological process of cerebral infarction