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甲氰咪胍(Cimetidine,商品名Tagamet)是现在较广用的组织胺H_2受体阻断剂,它对消化性溃疡的疗效渐被重视。H_2受体阻断剂对人胃酸分泌有强大抑制作用,不仅能抑制基础胃酸分泌,且能显著地抑制组织胺、五肽胃泌素、胆碱能介质氨乙吡唑(Betazol)和食物刺激所引起的胃酸分泌。1964年James和Black证实组织胺有两种不同受体即H_1受体和H_2受体。当H_1受体受组织胺作用时,引起各种器官诸如子宫、支气管的平滑肌收缩,血管舒张。此作用能被一般抗组织胺药物如苯海拉明所阻断。当H_2受体受组织胺作用时,引起胃酸分
Cimetidine (Cimetidine, trade name Tagamet) is now more widely used histamine H 2 receptor blockers, its efficacy of peptic ulcer gradually attention. H 2 receptor blockers on human gastric acid secretion has a strong inhibitory effect, not only can inhibit basal gastric acid secretion, and can significantly inhibit histamine, pentagastrin, cholinergic media, Caused by gastric acid secretion. In 1964, James and Black confirmed that histamine has two distinct receptors, the H 1 receptor and the H 2 receptor. When the H 1 receptor is affected by histamine, smooth muscle contraction and vasodilation of various organs such as uterus and bronchus are caused. This effect can be blocked by generic antihistamines such as diphenhydramine. When H 2 receptors by histamine effect, causing gastric acid points