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目的了解2型糖尿病视网膜病变(DR)患者的血清超敏C反应蛋白(hs-CRP)水平和血浆D-二聚体(D-dimer)、纤维蛋白原(FIB)水平,并探讨其临床意义。方法选取2013年10月—2015年12月成都医学院第一附属医院收治的2型糖尿病患者100例,根据眼底检查和眼底血管荧光造影检测结果,分为无DR组(NDR组,n=48)和存在DR组(DR组,n=52);另选取同时期在本院进行体检的健康成年人40例作为对照组。检测并比较3组受试者的血清hs-CRP及血浆D-dimer、FIB水平。结果 3组受试者性别、年龄、BMI、收缩压、舒张压,以及NDR组和DR组患者病程比较,差异无统计学意义(P>0.05)。DR组患者血清hs-CRP及血浆D-dimer、FIB水平高于NDR组患者,NDR组患者血清hs-CRP及血浆D-dimer、FIB水平高于对照组(P<0.05)。结论 DR患者血清hs-CRP及血浆D-dimer、FIB水平较高,表明其体内存在高凝和纤溶亢进状态,且炎性反应在DR病变中发挥着重要作用。
Objective To investigate the levels of serum hs-CRP and D-dimer and fibrinogen (FIB) in patients with type 2 diabetic retinopathy (DR) and to investigate their clinical significance . Methods 100 patients with type 2 diabetes admitted to the First Affiliated Hospital of Chengdu Medical College from October 2013 to December 2015 were divided into two groups according to fundus examination and fundus fluorescein angiography: NDR group (n = 48) ) And the presence of DR group (DR group, n = 52). Another 40 healthy adults were selected as the control group during the same period. The levels of serum hs-CRP and plasma D-dimer and FIB in the three groups were detected and compared. Results The gender, age, BMI, systolic blood pressure and diastolic blood pressure of the three groups of subjects, as well as the course of disease in NDR group and DR group, showed no significant difference (P> 0.05). Serum hs-CRP, plasma D-dimer and FIB in DR group were higher than those in NDR group. Serum hs-CRP, plasma D-dimer and FIB in NDR group were higher than those in control group (P <0.05). Conclusion The serum levels of hs-CRP and plasma D-dimer and FIB in patients with DR are higher than those in patients with DR, indicating that there is hypercoagulation and hyperfibrinolysis in DR patients. The inflammatory reaction plays an important role in the pathogenesis of DR.