据文献报告,骨髓增生异常综合征(MDS)或急性髓细胞白血病(AML)在诊断时骨髓纤维化的发生率为30～72%。有人推测纤维化是一种反应性应答,为网硬蛋白纤维化,严重增生病例占15%,常导致“干抽”或呈极度增生低下,无细胞成份可见,在此种情况下准确地区别MDS还是AML是很困难的。根据作者经验,由于涂片困难而不能确定诊断的病例占所有病例的10%。 According to the literature, the incidence of myelofibrosis at diagnosis of myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML) is 30-72%. It has been speculated that fibrosis is a reactive response to fibrosis of the reticulum, severe hyperplasia accounted for 15% of cases, often leading to “dry pumping” or extremely hyperplasia low, no cell components can be seen in this case accurately distinguish MDS or AML is very difficult. According to the authors’ experience, 10% of all cases were diagnosed due to smear difficulties.