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本文研究了维生素B_6的活性形式5′-磷酸吡哆醛(PALP)在大鼠上对妥布拉霉素(TOB)引起肾脏毒性的预防作用。作者从PALP 和TOB 体外的相互作用;PALP 对TOB 与肾刷状缘膜(BBMs)结合作用的影响;对肾内TOB 浓度的影响和对TOB 体内肾毒
This study investigated the prophylactic effect of pyridoxal 5’-phosphate (PALP), an active form of vitamin B_6, on the toxic effects of tobramycin (TOB) in rats. In vitro interaction between PALP and TOB; the effect of PALP on the binding of TOB to the brush border membrane (BBMs); the effect on TOB concentration in the kidney and the effect of nephrotoxication on TOB