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目的 :探讨 Ki- 6 7抗原在幕上高级别星形细胞肿瘤中的表达及其预后作用。方法 :使用 S- P免疫组化方法检测 6 3例原发性幕上高级别星形细胞肿瘤标本中 Ki- 6 7抗原的表达。单因素分析使用 Kaplan- Meier法 ,多因素分析使用 COX比例风险模型进行预后分析。结果 :Ki- 6 7指数在组织学分级 级、 级中分别为 (7.32± 3.2 4) %、(7.48± 4.5 5 ) % (P>0 .0 5 )。Ki- 6 7指数≤ 2 .5 %与 >2 .5 %的患者生存期分别为 (4 2 .42± 13.46 )月、(19.95± 11.0 7)月 (P<0 .0 1)。单因素及多因素分析均显示 Ki- 6 7指数是独立的预后因素。结论 :在幕上高级别星形细胞肿瘤中 ,组织病理分级本身对患者预后无意义 ;Ki- 6 7指数与病理级别无关 ;Ki- 6 7指数 >2 .5 %提示预后较差 ;Ki- 6 7指数是患者独立的预后因素
Objective: To investigate the expression of Ki-67 antigen in supratentorial astrocytic tumors and its prognostic significance. Methods: The expression of Ki-67 antigen in 63 cases of primary supratentorial high-grade astrocytoma specimens was detected by S-P immunohistochemistry. The Kaplan-Meier method was used for univariate analysis and the COX proportional hazard model was used for prognostic analysis in multivariate analysis. Results: The Ki- 6 7 index was (7.32 ± 3.2 4)% and (7.48 ± 4.5 5)% respectively in the histological grade and grade (P> 0.05). The survival of patients with Ki- 6 7 index ≤ 2.5% and> 2.5% were (42.42 ± 13.46) months and (19.95 ± 11.07) months, respectively (P <0.01). Univariate and multivariate analyzes showed that Ki- 6 7 index was an independent prognostic factor. CONCLUSION: Histopathologic grading itself has no significant prognosis in patients with high-grade astrocytic tumors. The Ki- 6 7 index has no relation with the pathological grade. Ki- 6 7 index> 2.5% suggests a poor prognosis. Ki- 6 7 Index is a patient independent prognostic factor