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目的观察不同方案治疗初次诊断2型糖尿病的疗效。方法选取156例初次诊断2型糖尿病患者作为研究对象,随机分为对照组77例和观察组79例。对照组予口服非磺脲类(瑞格列奈)+二甲双胍治疗,观察组予甘精胰岛素睡前皮下注射+二甲双胍口服治疗,同时两组均予以饮食、运动治疗,比较治疗前后两组患者的血糖达标时间、低血糖发生率、糖化血红蛋白、餐后2h血糖、空腹血糖的变化情况。采用SPSS 20.0统计软件进行分析,其中计量资料以(xˉ±s)表示,采用t检验,计数资料以率来表示,采用χ2检验。P<0.05为差异有统计学意义。结果观察组血糖达标时间(4.15±1.09)d明显短于对照组(5.09±1.54)d,两组相比差异有统计学意义(t=3.15,P<0.05);观察组的低血糖发生率为0.159次/人,对照组的低血糖发生率为0.396次/人,观察组的低血糖发生率明显低于对照组,差异有统计学意义(χ2=5.27,P<0.05);治疗后,两组患者的糖化血红蛋白、餐后2h血糖、空腹血糖均有所降低,且观察组降低效果更显著,差异有统计学意义(均P<0.05)。结论在饮食、运动治疗基础上,予胰岛素联合口服降糖药治疗初次诊断2型糖尿病,能有效控制患者的血糖,改善胰岛β细胞的功能,降低患者低血糖的发生率。
Objective To observe the efficacy of different regimens for the first diagnosis of type 2 diabetes mellitus. Methods 156 cases of newly diagnosed type 2 diabetic patients were randomly divided into control group (n = 77) and observation group (n = 79). The control group was treated with oral non-sulfonylurea (repaglinide) and metformin. The observation group was treated with glargine subcutaneously before bedtime and metformin orally. At the same time, both groups were treated with diet and exercise. The patients in both groups before and after treatment Blood glucose compliance time, the incidence of hypoglycemia, glycosylated hemoglobin, 2h postprandial blood glucose, fasting blood glucose changes. Using SPSS 20.0 statistical software for analysis, in which measurement data to (x ˉ ± s), using t test, count data to rate, using χ2 test. P <0.05 for the difference was statistically significant. Results The blood glucose level of observation group (4.15 ± 1.09) d was significantly shorter than that of control group (5.09 ± 1.54) d, the difference was statistically significant (t = 3.15, P <0.05) The incidence of hypoglycemia in the control group was 0.396 times / person, the incidence of hypoglycemia in the observation group was significantly lower than that in the control group (χ2 = 5.27, P <0.05); after treatment, The glycosylated hemoglobin, postprandial 2-hour blood glucose and fasting blood glucose were decreased in both groups, and the reduction effect in the observation group was more significant with statistical significance (all P <0.05). Conclusion On the basis of diet and exercise therapy, insulin and oral hypoglycemic agents are the first diagnosis of type 2 diabetes mellitus, which can effectively control the blood sugar, improve the function of pancreatic β cells and reduce the incidence of hypoglycemia.