论文部分内容阅读
本文作者从尿液提取肽类与氨基酸衍生物,已分离出119个组分,筛选其对细胞生长与DNA合成的作用。结果,较高浓度时能100%抑制肿瘤细胞的生长,而对正常细胞的抑制作用甚小,对离体的动物器官无明显作用。用自由流动电泳法分离自尿液提取的肽类与氨基酸衍生物,分离出二大类,一类化合物对单一、专一型肿瘤有抑制作用;另一类有广谱抗肿瘤作用。后者称为抗瘤酮A(antineoplaston A) 用制备高压液相的方法进一步纯化A制得A_1、A_2、A_3、A_4和A_5。通过高压液相对磺化聚苯乙烯的测定,它们不是同一物质,而是7～13个不同组份的混合物。A_1～A_5对组织
The authors extracted peptides and amino acid derivatives from urine and 119 components were isolated to screen for their effects on cell growth and DNA synthesis. As a result, the higher concentration of 100% can inhibit the growth of tumor cells, while the inhibition of normal cells is very small, no significant effect on isolated animal organs. Free-flow electrophoresis of peptides and amino acid derivatives isolated from the urine was used to isolate two major classes of compounds that inhibited single and specific tumors; the other had broad-spectrum anti-tumor effects. The latter is called antineoplaston A and A_1, A_2, A_3, A_4 and A_5 were obtained by further purification of A by preparing a high pressure liquid phase. By means of high-pressure liquid-phase measurement of sulfonated polystyrene, they are not the same substance but a mixture of 7 to 13 different components. A_1 ~ A_5 to the organization