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OBJECTIVE To investigate the expression of E-cadherin andCEA in serum in colorectal carcinoma and their relationship withliver metastasis.METHODS CEA level was measured post-operativelyby radioimmunoassay of 60 patients with colorectal cancer.Immunohistochemical analysis was used to evaluate theexpression of E-cadherin.RESULTS In liver metastasis group,24 patients (24/26,92.3%)were high level of CEA,but only 9 patients in non-liver metastasisgroup.The difference is significant (P=0.004).Expression ofE-cadherin significantly correlated with differentiation,but wasnot associated with Tstage or N stage.Liver metastatic rate innegative expression was higher than that in positive expression.And the survival analysis showed that time of liver metastasis wassignificant different in two groups (P<0.05).CONCLUSION The expression of CEA in serum can be usedto predict liver mestatasis of colorectal cancer after operation.E-cadherin,associated with tumor differentiation,is also a hopefulindicator for the prediction of liver metastasis in patients withcolorectal cancer.
OBJECTIVE To investigate the expression of E-cadherin and CEA in serum in colorectal carcinoma and their relationship withliver metastasis. METHHODS CEA level was measured post-operatively by radioimmunoassay of 60 patients with colorectal cancer. Immunohistochemical analysis was used to evaluate theexpression ofE-cadherin.RESULTS Of the 24 patients (24 of 26, 92.3%) were high level of CEA, but only 9 patients in non-liver metastasis group. The difference is significant (P = 0.004). Expression of E-cadherin significantly correlated with differentiation, but was associated with Tstage or N stage. Liver metastatic rate in negative expression was higher than that in positive expression. And the survival analysis showed showed that time of liver metastasis wassignificant different in two groups (P <0.05) .CONCLUSION The expression of CEA in serum can be usedto predict liver mestatasis of colorectal cancer after operation. E-cadherin, associated with tumor differentiation, is also a hopefulindicator for the prediction of liver metastasis in patients with colorectal cancer.