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目的 :探讨血清、尿金属蛋白酶组织抑制因子 - 1(TIMP - 1)浓度对肾脏纤维化的诊断价值。方法 :以酶联免疫吸附检测 (ELISA)方法检测健康者及肾脏病患者血清、尿TIMP - 1浓度。结果 :①以血清TIMP - 1浓度显著增高来判断肾组织有无纤维化敏感性为 89% ,特异性为 94% ,与肾活检符合率为 85 %。②尿TIPM - 1浓度与尿蛋白呈正相关 (r=0 .5 3,P <0 0 1)。结论 :血清TIMP - 1浓度可作为判断慢性肾脏病人肾纤维化的无损伤性检查指标
Objective: To investigate the diagnostic value of serum and urinary tissue inhibitor of metalloproteinase - 1 (TIMP - 1) in renal fibrosis. Methods: Serum and urinary TIMP - 1 levels were measured by enzyme - linked immunosorbent assay (ELISA) in healthy and nephritic patients. Results: ① The concentration of serum TIMP - 1 was significantly increased to determine whether the renal fibrosis sensitivity was 89%, the specificity was 94%, and the coincidence rate of renal biopsy was 85%. Urine protein and TIPM - 1 levels were positively correlated (r = 0.53, P <0.01). Conclusion: The serum concentration of TIMP - 1 can be used as noninvasive index to judge renal fibrosis in patients with chronic kidney disease