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作者研究小剂量抗胆碱能药物普鲁本辛是否能提高H_2受体拮抗剂甲腈咪胍治疗胃、十二指肠球部溃疡的疗效。方法治疗6周的研究:作者将经内窥镜检查确诊有胃、幽门前区或十二指肠溃疡的60例随意分成两组。A组:口服甲腈咪胍1g/d(200 mg每日3次,400mg睡前)加普鲁本辛15mg每日3次;B组:每天口服甲腈咪胍1g/d(200mg每日3次,400mg睡前)加安慰剂(每日3次)。研究期间停服抗酸剂以外的其他抗溃疡药物。治疗3和6周后对患者进行内窥镜、临床和生化指标的复查。维持治疗研究:对溃疡已愈合的患者给予维持治疗。随意分为3组:①甲腈咪胍400mg每日2次;
The authors study whether low-dose anticholinergic drugs, propylamine, can improve the curative effect of H 2 receptor antagonist cimetidine on gastric and duodenal ulcer. Methods Six-week study: The authors randomized 60 patients diagnosed with gastric, pyloric anterior or duodenal ulcer endoscopically to two groups. Group A: Citalopram 15 mg / day (200 mg three times a day, 400 mg before bedtime) plus 3 mg propranolol daily; Group B: Cetamidone 1 g / d orally daily (200 mg daily 3 times, 400 mg at bedtime) plus placebo (3 times daily). During the study to stop taking antacids other anti-ulcer drugs. Patients were reviewed for endoscopy, clinical and biochemical criteria 3 and 6 weeks after treatment. Maintenance Treatment Study: Maintenance treatment of ulcer patients who have healed. Randomly divided into 3 groups: ① nitrilemidine 400mg 2 times a day;