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对阻塞性睡眠呼吸暂停综合征（ＯＳＡＳ）患者７８例与年龄、性别和基础疾病相配对的无ＯＳＡＳ患者７５例，进行了昼夜尿量和次数的观察。结果显示：ＯＳＡＳ组与对照组尿量：白天分别为（９３６±１０２）ｍｌ和（１２３４±１３６）ｍｌ（Ｐ＜００１），夜间分别为（７６８±１２１）ｍｌ和（４１３±９５）ｍｌ（Ｐ＜００１）；尿次数夜间分别为３．９±０．８次和１．８±１．１次（Ｐ＜００５），两组白天尿次数无显著差异。提示ＯＳＡＳ可引起夜间多尿，重者可导致遗尿。机理可能为ＯＳＡＳ引起低氧血症使心钠素、醛固酮、儿茶酚胺、睾酮等分泌增加，中枢神经和肾功能损害等有关。
Seventy-eight patients with obstructive sleep apnea-hypopnea syndrome (OSAS) who did not have OSAS matched with age, gender and underlying diseases were enrolled in this study. Diurnal urine output and frequency were observed. The results showed that the urine output of OSAS group and control group were (936 ± 102) ml and (1234 ± 136) ml (P <001) during the day and (768 ± 121) ml and (413 ± 95) ml (P <001). Urine frequency was 3.9 ± 0.8 times and 1.8 ± 1.1 times at night (P <005) respectively. There was no significant difference in daytime diuresis between the two groups. Tip OSAS can cause nocturnal polyuria, severe cases can lead to enuresis. The mechanism may be hypoxemia caused by OSAS so that atrial natriuretic peptide, aldosterone, catecholamines, testosterone and other secretion increased, central nervous system and renal damage and so on.