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甘露醇是一种渗透性利尿剂,临床上广泛用于少尿性肾功能衰竭(肾衰)的诊断和预防,以及急性脑水肿和急性青光眼的治疗。近年发现其有潜在的肾脏毒性,本文报道1例急性肾衰患者,其发病可能与甘露醇中毒有关。患者为37岁黑人,男性,因青光跟局部给药治疗无效入院。有10年糖尿病史,以及存在糖尿病肾病引起的轻度肾功能不全,血尿素氮(BUN)20mg/dl,血肌酐(Cr)1.7mg/dl。入院时血压150/110mmHg,血BUN22mg/dl,血 Crl.9mg/dl,血清钠、钾及氯正常,
Mannitol is an osmotic diuretic that is clinically widely used in the diagnosis and prevention of oliguria renal failure (renal failure), and in the treatment of acute brain edema and acute glaucoma. In recent years, it was found to have potential renal toxicity, this article reports 1 case of acute renal failure, its incidence may be related to mannitol poisoning. 37-year-old black man, male, due to glaucoma and local drug treatment ineffective admission. A 10-year history of diabetes mellitus, mild renal insufficiency due to diabetic nephropathy, BUN 20 mg / dl, and serum creatinine 1.7 mg / dl. Admission blood pressure 150 / 110mmHg, blood BUN22mg / dl, blood Crl.9mg / dl, serum sodium, potassium and chloride normal,