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目的探讨突变型p53和Pgp蛋白在结直肠癌中表达的临床病理意义。方法采用免疫组化SP法检测751例结直肠癌组织中突变型p53和Pgp蛋白的表达,SPSS13.0统计分析两种蛋白表达的临床病理学意义及其相关性。结果突变型p53和Pgp蛋白在结直肠癌组织中的阳性率分别为50.7%(381/751)和72.2%(542/751);p53蛋白在直肠癌组织及中分化癌组织中的阳性率均明显高于其在结肠癌组织和高、低分化癌组织中的阳性率(P<0.05),Pgp蛋白的阳性率与所有临床病理参数均无明显相关性(P>0.05);在结直肠癌组织中,突变型p53和Pgp蛋白的表达呈正相关性(P<0.05)。结论结直肠癌组织中存在突变型p53和Pgp蛋白的异常表达,联合检测这两种蛋白或许对结直肠癌多药耐药的分子机制提供一定的临床依据。
Objective To investigate the clinicopathological significance of the expression of mutant p53 and Pgp proteins in colorectal cancer. Methods Immunohistochemical SP method was used to detect the expression of mutant p53 and Pgp proteins in 751 colorectal cancer tissues. SPSS13.0 was used to analyze the clinicopathological significance and correlation of the two protein expressions. Results The positive rates of p53 and Pgp protein in colorectal cancer tissues were 50.7% (381/751) and 72.2% (542/751) respectively. The positive rates of p53 protein in colorectal cancer tissues and moderately differentiated carcinoma tissues (P <0.05). The positive rate of Pgp protein had no significant correlation with all clinical and pathological parameters (P> 0.05). In colorectal cancer tissues, In the tissue, the expression of mutant p53 and Pgp protein was positively correlated (P <0.05). Conclusion The abnormal expression of mutant p53 and Pgp proteins in colorectal cancer tissues may exist. Combined detection of these two proteins may provide some clinical evidences for the molecular mechanism of multidrug resistance in colorectal cancer.