端粒酶活性在各种恶性肿瘤及肿瘤衍生的细胞株显著上调,而且与肿瘤细胞的增殖、分化密切相关。端粒酶活性及其催化亚基的检测有助于鉴别诊断内分泌腺良、恶性肿瘤,如甲状腺、肾上腺及卵巢的肿瘤,尤其两者的定量检查更具良好前景。端粒酶活性检测可能较病理检查更能判断肾上腺癌的预后,对卵巢肿瘤的诊断及治疗的指导价值很大。 Telomerase activity in a variety of malignant tumors and tumor-derived cell lines significantly upregulated, but also with the proliferation and differentiation of tumor cells are closely related. Detection of telomerase activity and its catalytic subunit is helpful for the differential diagnosis of benign and malignant tumors of the endocrine gland, such as thyroid, adrenal and ovarian tumors. In particular, the quantitative examination of both of them has a good prospect. Detection of telomerase activity may be more than the pathological examination to determine the prognosis of adrenal cancer, ovarian cancer diagnosis and treatment of great guiding value.