类风湿性关节炎是一种全身性自身免疫性疾病,Ⅱ型胶原是该病最关键的抗原之一。在患者的血清和关节腔中,均可发现大量的抗Ⅱ型胶原抗体和自身反应性T细胞。自上个世纪90年代起,国际上对类风湿性关节炎新的免疫治疗策略进行了探索,然而,目前国际上的探索仅限于T细胞免疫或T细胞肽疫苗,尚无针对特异性抗原的治疗性疫苗。 Rheumatoid arthritis is a systemic autoimmune disease, type Ⅱ collagen is one of the most critical antigens of the disease. In patients with serum and joint cavity, can be found in a large number of anti-type II collagen antibody and autoreactive T cells. Since the 90s of last century, the international immunotherapy strategy for rheumatoid arthritis has been explored. However, the current international exploration is limited to T-cell or T-cell peptide vaccines. There is no specific antigens Therapeutic vaccine.