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目的探讨慢性乙型肝炎、乙型肝炎肝硬化和原发性肝癌患者血清乙型肝炎病毒表面大蛋白(HBV-LP)水平差异及意义。方法选取2014年8月~2015年12月我院诊治的慢性乙型肝炎患者508例,乙型肝炎肝硬化患者74例,原发性肝癌患者29例,采用ELISA法检测血清HBV-LP水平,采用FQ-PCR法检测血清HBV DNA水平。结果慢性乙型肝炎、乙型肝炎肝硬化和原发性肝癌患者血清HBV-LP阳性率分别为77.2%、82.4%和89.7%,血清HBV DNA阳性率分别为78.9%、83.8%和93.1%;3组血清HBV-LP水平分别为(9.78±4.25)μg/L、(17.24±8.63)μg/L和(38.65±19.38)μg/L,差异有统计学意义(P<0.05)。结论 HBV-LP是乙型肝炎病毒感染者血清重要的标记物,与血清HBV DNA存在某种相关性,其检测的意义值得探讨。
Objective To investigate the difference and significance of serum hepatitis B virus surface protein (HBV-LP) levels in patients with chronic hepatitis B, hepatitis B cirrhosis and primary liver cancer. Methods A total of 508 patients with chronic hepatitis B, 74 patients with hepatocirrhosis and 29 patients with primary hepatocellular carcinoma were enrolled in our hospital from August 2014 to December 2015. Serum HBV-LP levels were measured by ELISA, Serum HBV DNA levels were measured by FQ-PCR. Results The positive rates of serum HBV - LP in patients with chronic hepatitis B, hepatitis B cirrhosis and primary liver cancer were 77.2%, 82.4% and 89.7% respectively, and the positive rates of serum HBV DNA were 78.9%, 83.8% and 93.1% respectively. The levels of serum HBV-LP in the three groups were (9.78 ± 4.25) μg / L, (17.24 ± 8.63) μg / L and (38.65 ± 19.38) μg / L respectively, with statistical significance (P <0.05). Conclusion HBV-LP is an important serum marker of hepatitis B virus infection and has some correlation with serum HBV DNA. The significance of detection is worth exploring.