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甲氰咪脈(Cimetidin)的合成、问世并投入临床使用六年多来,国内外各家治疗消化性溃疡的近期疗效基本相似,但也有不少毒副作用,据报道,毒副作用的发生率为14～35％。现将文献对本药的评价简述如下: 药物疗效及理论基础甲氰咪胍系组织胺H_2受体阻断药。组织胺有促进胃酸分泌、加快心率、抑制大白鼠子宫收缩等作用,是由于兴奋H_2受体所致。这些作用可被H_2受体阻断药如甲氰咪胍所对抗。理论上甲氰咪胍不仅对人和动物自发的胃酸分泌有抑制作用,对组织胺、五肽胃泌素、食物与低血糖等所引起的胃酸分泌也有较强的抑制作用。但对临床疗效的看法仍有分岐。本药对治疗上消化道出血的作用机理认为主要在于它具有拮抗组织胺刺激壁细胞的泌酸作用,对胃泌素和兴奋迷走神经所致壁细胞泌酸有强力抑制功效。用药后胃酸中氢离子浓度下降、pH增高,从而阻止氢离子向胃粘膜内逆扩散,
Cimetidin (Cimetidin) synthesis, come out and put into clinical use for more than six years, the domestic and foreign treatment of peptic ulcer in the near future effect is similar, but there are many side effects, it was reported that the incidence of side effects 14 ~ 35%. Now the literature on the evaluation of the drug is summarized as follows: Therapeutic efficacy and theoretical basis Cimetidine Department of histamine H_2 receptor blocker. Histamine has to promote gastric acid secretion, speed up heart rate, inhibition of uterine contraction in mice and other effects, is due to excited H_2 receptors. These effects can be antagonized by H 2 receptor blockers such as cimetidine. In theory, cimetidine not only inhibits spontaneous gastric acid secretion in humans and animals, but also inhibits gastric acid secretion caused by histamine, pentagastrin, food and hypoglycemia. However, the clinical efficacy of the views are still divided. The drug on the treatment of upper gastrointestinal bleeding mechanism of action that it has antagonized histamine to stimulate parietal cells of the acid secretion of gastrin and excitatory vagus nerve wall caused by pessary oxytocin has a strong inhibitory effect. Hydrochloric acid in the stomach after the drug concentration decreased, pH increased, thus preventing the hydrogen ion to the gastric mucosa inverse proliferation,