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目的:利用自体半腱肌腱移植建立距跟骨间韧带重建的动物模型。方法:将72只新西兰白兔随机分为重建组、切断组和对照组。分别于4周、8周、16周、32周取材,对3个实验组术前术后体重变化,重建韧带的影像学、组织学和生物力学结果以及术后距下关节的活动范围进行评估。结果:术后8周以后实验动物体重变化出现差别,韧带切断组较重建组体重多增加0.32 kg(P=0.04);影像学、组织学和生物力学均支持移植韧带成活,生物力学研究发现韧带牵拉时出现2个张力屈服点;术后3组距下关节冠状面(P<0.05)和水平面(P<0.001)活动度差异有统计学意义。结论:利用自体半腱肌腱移植重建距跟骨间韧带可有效恢复距下关节的解剖和功能。移植韧带经过坏死、塑形改建、成熟的过程与骨道形成末端结构愈合。对于研究距下关节稳定性、韧带断裂后关节的继发性改变、韧带移植重建的转归提供了良好的动物模型材料。
OBJECTIVE: To establish an animal model of reconstruction of the interosseous talocalcaneal ligament using autologous semitendinosus tendon transplantation. Methods: Seventy-two New Zealand white rabbits were randomly divided into reconstructive group, sever group and control group. At 4 weeks, 8 weeks, 16 weeks and 32 weeks respectively, the changes of body weight, reconstruction of ligaments, imaging results, histology and biomechanics and the range of motion of subtalar joint after operation were evaluated in 3 experimental groups . Results: After 8 weeks, the changes of body weight were different. The body weight of the ligament resection group was increased by 0.32 kg (P = 0.04) more than that of the control group. Imaging, histology and biomechanics supported the survival of the graft ligament. The biomechanical study found that the ligament There were two yield points of tension during pulling. There were significant differences in the activities of coronal plane (P <0.05) and horizontal plane (P <0.001) between the three groups. Conclusion: Autologous semitendinosus tendon graft reconstruction between the talocalcaneal ligament can effectively restore the anatomy and function of the subtalar joint. After the graft ligament necrosis, plastic reconstruction, the process of maturation and the formation of the distal bone structure healing. It provides a good animal model material for studying the stability of the subtalar joint, the secondary change of the joint after ligament rupture and the outcome of the ligament transplantation and reconstruction.