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目的探讨宫颈高危型HPV感染与人工流产次数的关系,为本地区女性防治宫颈癌提供有针对性的健康教育。方法采用病例-对照研究设计,选取2012年1月—2015年12月,在开滦总医院、唐山市人民医院、唐山市协和医院、开滦总医院林西医院门诊及查体中心行宫颈液基细胞学检查及人乳头瘤病毒(HPV)基因检测的查体者的资料,并根据体检结果进行分组。将筛查出的139例高危型HPV感染阳性患者作为病例组;同期于上述五所医院门诊及查体中心行体检者,高危型HPV感染阴性患者173例作为对照组。通过问卷调查获取资料。应用SPSS19.0软件进行统计分析。用χ2检验及多因素非条件Logistic回归模型分析宫颈高危型HPV感染与人工流产次数的关系。结果高危型HPV感染在不同人工流产次数组的分布差异均有统计学意义(P<0.01);多因素非条件Logistic回归分析显示:人工流产手术史是宫颈高危型HPV感染的首要危险因素(OR=3.02,95%CI为1.06~8.65)。结论人工流产次数与宫颈高危型HPV感染具有相关性。加强女性健康性教育,减少人工流产次数,能有效预防高危型HPV的传播以及宫颈癌的发生。
Objective To explore the relationship between the high risk HPV infection and the number of induced abortion and to provide targeted health education for the prevention and treatment of cervical cancer in this area. Methods The case-control study design was adopted. From January 2012 to December 2015, we selected cervical fluid from outpatients and physical examination center of Kailuan General Hospital, Tangshan People’s Hospital, Tangshan Union Hospital and Kailuan General Hospital, Based cytology and human papillomavirus (HPV) detection of physical examination of those who were based on the physical examination results were grouped. A total of 139 cases of high-risk HPV-positive patients were screened out as the case group. In the same period, 173 cases of high-risk HPV-negative patients in the five outpatient clinics and physical examination centers were selected as the control group. Obtain information through questionnaire. Application SPSS19.0 software for statistical analysis. Χ2 test and multivariate non-conditional logistic regression model were used to analyze the relationship between high-risk cervical HPV infection and the number of induced abortion. Results The distribution of high-risk HPV infection in different time series of abortion was statistically significant (P <0.01). Multivariate non-conditional logistic regression analysis showed that the history of induced abortion was the most important risk factor of cervical high-risk HPV infection = 3.02, 95% CI 1.06 ~ 8.65). Conclusion The number of induced abortion is associated with high risk HPV infection. Strengthening women’s sexual health education and reducing the number of induced abortions can effectively prevent the spread of high-risk HPV and cervical cancer.