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目的了解妊娠期肝病(LDOP)在嘉兴地区的发病情况、病因构成以及妊娠结局。方法收集2013年1月-2015年12月在嘉兴市妇幼保健院诊治的41 878例孕产妇的临床资料并进行回顾性研究,应用SPSS 13.0进行数据分析。结果在妊娠期肝病中,妊娠期高血压疾病合并肝损伤397例(64.3%),妊娠期肝内胆汁淤积综合征(ICP)109例(17.7%),妊娠剧吐合并肝功能损害83例(13.5%),HELLP综合征15例(2.4%),妊娠期急性脂肪肝(AFLP)13例(2.1%)。妊娠期肝病发病率为1.5%。妊娠期高血压疾病合并肝功能损害以及HELLP综合征孕妇的胎儿结局较差,其中早产率分别为58.9%和86.7%,围生儿死亡率分别为10.4%和11.8%。结论嘉兴地区妊娠期肝病发病率较低,母胎结局相对较好,病因构成主要为妊娠期高血压疾病。
Objective To understand the incidence of pregnancy-induced liver disease (LDOP) in Jiaxing, its etiology and pregnancy outcome. Methods The clinical data of 41 878 pregnant women who were diagnosed and treated in Jiaxing MCH from January 2013 to December 2015 were collected and retrospectively studied. Data were analyzed by SPSS 13.0. Results In the third trimester of pregnancy, there were 397 cases (64.3%) with hypertensive disorder complicating pregnancy, 109 cases (17.7%) with intrahepatic cholestasis syndrome (ICP) during pregnancy, 83 cases with hyperemesis gravidarum and hepatic dysfunction 13.5%), HELLP syndrome in 15 cases (2.4%) and acute fatty liver in pregnancy (AFLP) in 13 cases (2.1%). The incidence of liver disease during pregnancy was 1.5%. Hypertensive disorders complicating liver damage during pregnancy and HELLP syndrome have poor fetal outcomes, with preterm birth rates of 58.9% and 86.7%, and perinatal mortality rates of 10.4% and 11.8%, respectively. Conclusion The incidence of liver disease in pregnancy is low in Jiaxing area, and the result of maternal fetal birth is relatively good. The main cause of pregnancy is hypertensive disorders of pregnancy.