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服用药物引起的食管炎称为药物性食管炎(Medication-Induced Esophagitis,MIE),近20年来受到人们的重视。从1965年以来文献中报道有13种药物可引起食管炎(表1)。病变可发生在各年龄组的服药病人。病变可轻可重,从食管粘膜表面红肿、糜烂、浅表溃疡到深溃疡以及食管狭窄。临床表现可多种多样,但都有相似的起病过程,通常为服药后4到12小时内突发急性吞咽困难,伴胸骨后疼痛或吞咽时痛。奎尼丁引起的食管溃疡的症状可在几周后出现。Teplick等和Mason等发现服药的时间和方法与发病有关,在他们报道的病例中,发现病人在临睡前用少量水或不用水
Medication-induced esophagitis is called Medication-Induced Esophagitis (MIE), which has drawn people’s attention for nearly 20 years. Thirteen drugs have been reported in the literature since 1965 to cause esophagitis (Table 1). Lesions can occur in all age groups taking patients. Lesions can be light and heavy, from the surface of the esophageal mucosal swelling, erosion, superficial ulcers to deep ulcers and esophageal stenosis. Clinical manifestations can vary, but all have a similar onset of onset, usually acute dysphagia 4 to 12 hours after taking the medication, pain associated with sternum, or pain when swallowing. The symptoms of esophageal ulcer caused by quinidine can appear in a few weeks. Teplick et al and Mason, etc. found that the time and method of taking medication and the incidence, in their reported cases, found that patients before going to sleep with little or no water