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目的探讨急性有机磷农药中毒(AOPP)患者尿视黄醇结合蛋白(RBP)检测的意义。方法用ELISA法检测71例AOPP患者尿RBP含量,并与45例正常对照组进行比较。结果71例AOPP患者,其中20例中毒后尿RBP逐渐增高,且随着病情的发展尿蛋白阳性;51例尿蛋白阴性患者尿RBP含量增高18例,在中毒后第1、3、5、7天尿RBP含量中位数分别为10·1、42·3、22·7、9·1mg/molCr,均高于正常对照(8·1mg/molCr),差异有显著性(P<0·05),且中毒愈重,尿RBP增高愈明显。结论检测AOPP患者尿RBP对肾损害的早期诊断具有重要意义。
Objective To investigate the significance of detecting retinol binding protein (RBP) in patients with acute organophosphorus pesticide poisoning (AOPP). Methods Urinary RBP levels in 71 patients with AOPP were detected by ELISA and compared with 45 normal controls. Results 71 cases of AOPP patients, of which 20 cases of urine RBP gradually increased, and with the development of the disease urinary protein positive; 51 cases of urinary protein-negative urine RBP increased in 18 cases, after poisoning 1,3,5,7 The median urinary RBP levels were 10 · 14 · 2 · 3 · 22 · · · · · · · · · · · · · · · · · · · · 1 mg · mol-1 ), And the more poisoning, urinary RBP increased more obvious. Conclusion Detecting urinary RBP in patients with AOPP is of great significance in the early diagnosis of renal damage.